Biovert

Drug Information of Biovert

 

 

Indications:

Vertigo
Meniere's Syndrome…..
Dizziness,Tinnitus,Nausea
Headache & accompanied by loss of hearing symptomatic
Treatment of
Vestibular vertigo

•Effective histamine antalogue controls vertigo in patient of Meniere's Syndrome.

• Meniere's Syndrome occurs when there is a buildup of fluid within the inner ear. This causes symptoms such as Tinnitus (Bussing in the ear), Deafness and vertigo (a spinning sensation often causing vomiting).

• Betahistine works by reducing the amount of fluid in the inner ear and there fore relieves these symptoms.

 

Betahistine

Betahistine has a very strong affinity as an antagonist for histamine H3 receptors and a weak affinity as an agonist for histamine H1 receptors. Betahistine seems to dilate the blood vessels within the inner ear which can relieve pressure from excess fluid and act on the smooth muscle. Betahistine has two modes of action. Primarily, it has a direct stimulating (agonistic) effect on H1 receptors located on blood vessels in the inner ear. This gives rise to local vasodilation and increased permeability, which helps to reverse the underlying problem of endolymphatic hydrops. More importantly, betahistine has a powerful antagonistic effects at H3 receptors, thereby increasing the levels of neurotransmitters histamine, acetylcholine, norepinephrine, and serotonin released from the nerve endings. The increased amounts of histamine released from histaminergic nerve endings can stimulate receptors. This stimulation explains the potent vasodilatory effects of betahistine in the inner ear, that are well documented.

 

Adverse effects

• Headache.

• Low level of gastric side effects.

• Insomnia

• Nausea can be a side effect, but the patient is generally already experiencing nausea due to the vertigo so it goes largely unnoticed.

• Patients taking betahistine hydrochloride may experience several hypersensitivity and allergic reactions. In the November 2006 issue of "Drug Safety," Dr. Sabine Jeck-Thole and Dr. Wolfgang Wagner reported that betahistine hydrochloride may cause several allergic and skin-related side effects. These include rash in several areas of the body; itching and hives; and swelling of the face, tongue and mouth. Other hypersensitivity reactions reported include tingling, numbness, burning sensations, shortness of breath and laboured breathing. The study authors suggest that hypersensitivity reactions may be a direct result of betahistine's role in increasing histamine levels throughout the body. Hypersensitivity reactions quickly subside after betahistine has been discontinued.


 



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