Bzcal 60K

Drug Information of Biovert
Cholecalciferol 60,000 IU Tablet

 

 

Indications:

• Hypocalcemia
• Refractory Rickets
• Vitamin D deficiency
• Hypoparathyroidism
• In managements of type-2

 

Cholecalciferol

 Correct vitamin D deficiency
 Promotes Bones Density
 Builds and maintains bones
 Reduces the risk of rickets
 Improves cardiac dysfunction
 Ensures proper growth and development
 Increases calcium absorption in the intestine

• Cholecalciferol is synthesized in the skin from 7-dehydrocholesterol under the action of ultraviolet B light. It reaches an equilibrium after several minutes depending on several factors including conditions of sunlight (latitude, season, cloud cover, altitude), age of skin, and color of skin

. • Hydroxylation in the endoplasmic reticulum of liver hepatocytes of cholecalciferol to calcifediol (25-hydroxycholecalciferol) by 25-hydroxylase is loosely regulated, if at all, and blood levels of this molecule largely reflect the amount of vitamin D3 produced in the skin or the vitamin D2 or D3 ingested

. • Hydroxylation in the kidneys of calcifediol to calcitriol by 1-alpha-hydroxylase is tightly regulated (stimulated by either parathyroid hormone or hypophosphatemia) and serves as the major control point in production of the most active circulating hormone calcitriol (1,25-dihydroxyvitamin D3).

Cholecalciferol is produced industrially for use in vitamin supplements and to fortify foods by the ultraviolet irradiation of 7-dehydrocholesterol extracted from lanolin found in sheep's wool. Paraphrasing a more detailed explanation,[7] cholesterol is extracted from wool grease and wool wax alcohols obtained from the cleaning of wool after shearing.



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